The potential for drug interactions with grapefruit should be considered in cases in which an increase or decrease of the coadministered drug is clinically important. In patients with major myocardial structural disorders, pink grapefruit should be avoided due to proarrhythmic effects. In a meta-analysis evaluating effects on body weight, fresh grapefruit, grapefruit juice, or grapefruit capsules (with naringin dosages of the formulations ranging from 81 to 142 mg) were administered for 6 or 12 weeks in the included randomized controlled trials. Weight and related parameters: 8 oz (237 mL) of grapefruit juice, or half of a fresh grapefruit, 3 times a day before each meal for 12 weeks was used in a clinical trial evaluating effects on body weight and metabolic syndrome.

Periodontitis: 2 grapefruits per day for 2 weeks were consumed in a trial evaluating effects on vitamin C status of patients with periodontitis. In one cohort of women, 2 to 4 servings per week or 5 or more servings per week of grapefruit (1 serving of grapefruit was one-half of a grapefruit) also reduced risk. In a trial of healthy postmenopausal women, 340 mL/day (providing 201 mg/day of naringenin) of grapefruit juice was administered for 6 months to evaluate effects on arterial stiffness.ĭiabetes risk: Pooled results from 3 prospective longitudinal cohort studies (N=187,382 3,464,641 person-years of follow-up) reported consumption of 2 to 4 servings per week of grapefruit to reduce the risk of type 2 diabetes. Fresh grapefruit, grapefruit juice, and grapefruit capsules for 6 or 12 weeks, with naringin doses of the formulations ranging from 81 to 142 mg/day, have been used in randomized controlled trials evaluating effects on cardiovascular risk factors in obese adults. Quality clinical trials upon which to base therapeutic dosing recommendations for grapefruit are limited.Ĭardiovascular risk factors: 1 grapefruit daily for 30 days has been used in a clinical trial to improve lipid profiles. Consumption of whole grapefruit has been shown in several analyses to provide improved benefits compared to the juice. Antimicrobial effects have been reported. Some trials also demonstrate reductions in body fat and waist circumference but data regarding use for weight loss are equivocal. Limited data suggest potential benefit for certain patient populations in reducing the risk of renal stones and type 2 diabetes, as well as some cardiovascular risk factors (including improvement in systolic blood pressure, high-density lipoprotein cholesterol, and arterial stiffness). High-quality clinical trials are lacking to support therapeutic applications of grapefruit and grapefruit juice. It's not the onus of a business to put this theater on their foods unless the chemical is dangerous to a majority (such as tar in tobacco).Scientific Name(s): Citrus paradisi Macfad. Not only that it's incredibly rare on a population basis (~1/15,000). To exemplify this most diet soda contains a required notice 'caution phenylketonurics: contains phenylalanine.' Did you know this? Do you think the average person finds utility in this? If you are a phenylketonuric you most likely already know about the risks and what to avoid with your condition. All of these would be better solutions than some safety theater like a warning label on an unambiguously safe product except to people taking certain medications. You could run commercials about pharmaceutical pamphlets, you could fund a website where people could find their drug and learn quickly about interactions, you could make it a legal obligation of doctors and pharmacists to both tell you the necessary precautions with your medication. If you really desire some sort of campaign to stop this there are ways that don't impede on businesses and other's lives. So the onus is on me to resolve this edge case. My burden taking a medication is on a percentage basis an edge case for the general 'eating stuff' problem. I just know that I don't know something about a drug I am taking and should figure out more. I'm not even what I would consider 'health conscious'. If I still don't have answers I call my doctor, or find a doctor I can call. If it's a particularly dangerous med when used incorrectly I consult with the pharmacist. If I am on a medication I always read the pamphlet.

Grapefruit and cholesterol meds